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ElevATP®

ElevATP®
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ElevATP Common Name

ElevATP®

Top Benefits of ElevATP

  • Supports athletic performance and body composition*
  • Supports power output and training volume*
  • Helps reduce performance decrements associated with overreaching*
  • Supports lean muscle and strength*
  • Supports healthy aging*
  • Supports ATP production*
  • Supports mitochondrial structure and function*
  • Supports cellular responses and antioxidant defenses*
  • Supports healthy gut microbiota* 

What is ElevATP?

ElevATP® is a proprietary, clinically researched combination of a water extract of “ancient peat” (fossilized plants) and apple extract. The ancient peat contains 70 plant-derived inorganic microelements. It is especially rich in carbon, magnesium, nitrogen, oxygen, and sulfur. The apple extract is made from apple peel and contains 10 apple polyphenols. ElevATP® was designed to support mitochondrial energy-producing processes to stimulate cellular energy  production in the form of ATP. Having extra ATP allows our cells to do more things better, upregulating health, performance, and metabolism.

Neurohacker’s ElevATP Sourcing

elevATP® is a clinically tested product with human studies for sports performance, body composition, and elevating cellular energy in the form of ATP.

Created by FutureCeuticals, Inc., an industry leader in the research, development and manufacture of fruit, vegetable, and grain-based products.

elevATP® was awarded ingredient of the year in the sports nutrition category by Nutraingredients-USA Awards for 2018.

elevATP® is Non-GMO Project Verified, vegan, GRAS (generally recognized as safe) and gluten free.

elevATP® is a registered trademark of VDF FutureCeuticals, Inc. elevATP® products are protected by US patent no. 9,327,005, used under license.

ElevATP Dosing Principles and Rationale

The dose of elevATP® used in human clinical research has been 150 mg once daily. We opted to use this proven dose in our formulation. In general, we consider polyphenols, like those found in the apple peel extract component of elevATP® to be subject to hormetic dosing principles (see Neurohacker Dosing Principles). Flavonoids are additive, and often synergistic with other polyphenol compounds, so the combination of all polyphenols in a formulation should be considered when determining dosage (not the amount of a single polyphenol molecule in isolation).

ElevATP Key Mechanisms

Mitochondrial function

  • Stimulates ATP production [1–5]
  • Protects from mitochondrial dysfunction [1]
  • Promotes mitochondrial dehydrogenase activity [6]
  • Protects from complex I (NADH-coenzyme Q reductase) inhibition [4]
  • Supports mitochondrial β-oxidation performance [5]
  • Upregulates peroxisome proliferator-activated receptor alpha (PPARα) [7]

Mitochondrial structure

  • Supports healthy mitochondrial membrane potential [1]
  • Supports healthy mitochondrial DNA (mtDNA) [6]
  • Supports healthy mitochondrial morphology [5]

Mitochondrial biogenesis

  • Upregulates peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α) [5,6,8]

Exercise performance (ergogenic effect)

  • Supports endurance performance  [9,10]
  • Supports strength performance  [11]
  • Supports muscle structure and function [7,9]
  • Upregulates lean mass [12,13]

Skeletal system

  • Supports cartilage structure [6]

Antioxidant defenses

  • Upregulates antioxidant enzymes (superoxide dismutase [SOD]) [6,8]
  • Downregulates oxidative stress [1,4,5,8]
  • Replenishes glutathione (GSH) levels [1]
  • Supports healthy mitochondrial redox status [1,4,5]

Cellular signaling

  • Downregulates the expression of proinflammatory molecules – tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), nuclear factor κB (NFκB), inducible nitric oxide synthase (iNOS) [5,8]

Gut microbiota

  • Regulates the composition of the gut microbiota [14,15]
  • Regulates gut microbial metabolism [14,16]

Healthy aging and longevity 

  • Upregulates SIRT-1 [17] 
  • Downregulates mTOR signaling (small effect) [3]


REFERENCES 

[1] Carrasco-Pozo C, et al. J Pharm Pharmacol. 2010;62(7):943-950. doi:10.1211/jpp.62.06.0017
[2] Reyes-Izquierdo T, et al. J Aging Res Clin Practice. 2014;3:56-60.
[3] Reyes-Izquierdo T, et al. J Aging Res Clin Practice. 2013;2:178-184.
[4] Carrasco-Pozo C, et al. J Agric Food Chem. 2011;59(21):11501-11508. doi:10.1021/jf202621d
[5] Yeganeh PR, et al. J Nutr Biochem. 2018;57:56-66. doi:10.1016/j.jnutbio.2018.03.008
[6] Masuda I, et al. Sci Rep. 2018;8(1):7229. doi:10.1038/s41598-018-25348-1
[7] Nakazato K, et al. Med Sci Sports Exerc. 2007;39(6):934-940. doi:10.1249/mss.0b013e31803df4bc
[8] Denis MC, et al. PLoS One. 2013;8(1):e53725. doi:10.1371/journal.pone.0053725
[9] Mizunoya W, et al. PLoS One. 2015;10(7):e0134303. doi:10.1371/journal.pone.0134303
[10] Reyes-Izquierdo T, et al. Journal of Nutraceuticals and Food Science. 2016;1(2):11.
[11] Joy JM, et al. BMC Complement Altern Med. 2016;16:224. doi:10.1186/s12906-016-1222-x
[12] Joy JM, et al. Appl Physiol Nutr Metab. 2015;40(11):1171-1177. doi:10.1139/apnm-2015-0241
[13] Joy JM, et al. J Int Soc Sports Nutr. 2016;13:25. doi:10.1186/s12970-016-0136-9
[14] Koutsos A, et al. Nutrients. 2017;9(6). doi:10.3390/nu9060533
[15] Cuervo A, et al. Nutrients. 2015;7(2):1301-1317. doi:10.3390/nu7021301
[16] Ravn-Haren G, et al. Food Funct. 2018;9(5):2931-2941. doi:10.1039/c7fo01932g
[17] Sunagawa T, et al. Planta Med. 2011;77(2):122-127. doi:10.1055/s-0030-1250204