Lion’s Mane

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Overview:
Lion’s Mane is a mushroom with neuroprotective and nootropic effects. Lion’s Mane can improve memory and reasoning.

Scientific Name:
Hericium erinaceus

Mechanisms:

  • Increases NGF levels in the brain – enhanced neuronal growth, regeneration and synaptic plasticity[1]
  • Improves myelination – enhanced neuronal communication and nerve regeneration[2]
  • Increases long-term synaptic potentiation – improved memory[3,4]
  • Decreases glutamatergic transmission – decreased neuronal excitability and excitotoxicity[3,4]
  • Protects neurons from endoplasmic reticulum stress[3,4]
  • Anxiolytic[5]
  • Anti-inflammatory effects[6]
REFERENCES

[1] Lai PL, et al (2013). Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms, 15(6):539-54. doi: 10.1615/IntJMedMushr.v15.i6.30
[2] Kolotushkina EV, et al (2003). The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol Zh, 49(1):38-45. PMID: 12675022
[3] Phan CW, et al (2015). Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol, 35(3):355-68. doi: 10.3109/07388551.2014.887649
[4] Sabaratnam V, et al (2013). Neuronal health – can culinary and medicinal mushrooms help? J Tradit Complement Med, 3(1):62-8. doi: 10.4103/2225-4110.106549
[5] Nagano M, et al (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res, 31(4):231-7. doi: 10.2220/biomedres.31.231
[6] Geng Y, et al (2014). Anti-inflammatory activity of mycelial extracts from medicinal mushrooms. Int J Med Mushrooms, 16(4):319-25. doi: 10.1615/IntJMedMushrooms.v16.i4.20