Phosphatidylserine: Why You Should Include it in Your Diet

Phosphatidylserine: Why You Should Include it in Your Diet

What is Phosphatidylserine?

Phosphatidylserine can be quite a mouthful when trying to say it, so it’s probably easier to go with its abbreviation: PS. PS was discovered back in 1941 by Jordi Folch and Howard A. Schneider and first grew in popularity in Europe. Thanks to clinical trials conducted in Italy, word of its effectiveness at memory enhancement quickly spread to the rest of the world, leading to its current state as a much sought after nootropic.

PS is an aminophospholipid and amino acid derivative which is produced naturally within the body. In fact, it’s a phospholipid which makes up a sizable portion of the human brain. It should be noted, however, that while the body can produce PS on its own, most of it comes from our food. Unfortunately, the modern diet often doesn’t contain enough PS. Unless you consistently have a large helping of Atlantic mackerel, chicken heart, soy lecithin, bovine brain, and Atlantic herring, chances are you’re going to need to get your PS from a supplement. PS also acts as a signaling agent for apoptosis, which is a standard process of cell death that is necessary for an organism to grow and develop.

Benefits of Phosphatidylserine

PS is a nootropic that has been the subject of a large number of studies intended to take a closer look at the variety of phosphatidylserine benefits. Some of these benefits stand out as particularly strong.

PS Helps With Stress

Optimizing your mood may mean using PS in large part due to phosphatidylserine’s relationship to cortisol. Cortisol is often referred to as the “stress hormone” partly because it is involved in the body’s response to stress. PS may play a role in reducing cortisol in your body, thus having a positive benefit on your stress levels. That goes for physical stress, like the kind you would experience from exercise, but PS also has an impact on reducing mental stress in social situations.

PS Aids in Cognitive Enhancement

PS may have some neuroprotective properties, which can help people enhance their cognition. This can come in several different forms, most prominently in the learning process. With PS as part of the diet, one study has shown that people may be able to increase the rate at which they make calculations while also improving their overall accuracy in getting information right. Sometimes these benefits are most noticeable when people are tired, or when they are about to engage in a physical activity such as exercise. By extension, this may indicate that taking PS is something athletes would want to look into, though non-athletes can certainly benefit as well.

PS Benefits Memory

In the realm of memory, research has suggested that PS could help with the symptoms of cognitive decline, primarily helping people recall information more quickly. Part of what may explain this benefit is the nutrient’s role in the production of acetylcholine, basically increasing the amount found in the body. Increased quantities of acetylcholine may help to enhance memory. In fact, this particular increase may help in other areas, such as improved learning and greater accuracy.

PS Works Well With Other Supplements

Phosphatidylserine may also help to enhance other supplements which positively impact the brain. One great example of an excellent brain supplement is curcumin, a compound extracted from turmeric. Curcumin works by increasing the flow of blood to your brain while also increasing the production of dopamine and serotonin. One problem curcumin has, though, is that it’s difficult to absorb. That’s where PS can help with your supplementation. Taking PS helps to enhance curcumin’s biolavailability, meaning more of it gets used. PS also works well with other nutrients like Ginkgo biloba and fish oil.

Taking Phosphatidylserine

PS is a natural compound, so it’s a safe nootropic recommended for inclusion in any diet. PS has been found to provide some excellent benefits for your brain, such as improving memory, helping with stress, and enhancing one’s learning ability. Combine these with its beneficial relationship with other supplements, and PS demonstrates its high value with ease.


  • Kathryn
    At 100mg, it made me feel tired and depressed.
  • Guest
    Just tried it this morning so don't know effects yet but a person at health food store recommended. It was an ingredient in a sleep supplement (lower dose) that I stopped taking as too expensive but always woke up feeling good when I took it so I'm curious if it was this ingredient that gave the good effects.
  • kevin obrien
    please understand that every cell wall of every cell in your entire body needs PS. please understand that : cell wall failure = almost all disease + ageing etc. millions of people take it daily and taking it is "old news" in the health industry cell wall failure leads to organ failure= death
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