The Science Behind Qualia Night
Qualia Night was designed to offer comprehensive sleep support by optimizing your body’s regenerative power at night. It supports better sleep without relying on botanical sedatives or giving melatonin. It is designed to help the brain better regulate the ensemble of molecules needed to fall asleep, stay asleep, and wake feeling refreshed.
Neurohacker Collective's products are formulated based on complex systems science. This emerging scientific paradigm (1) supports upregulation of multiple pathways and processes, (2) identifies and takes advantage of nutrient synergies, and (3) embraces the Goldilocks zone, or just-right amount, when it comes to ingredients and dosage.
While published studies are the foundation of what we do at Neurohacker Collective, we also take into account the experiences of biohackers and the growing community of self-experimenters, which are leading a revolution in citizen science.
It’s this combination of complex systems and citizen science that places Neurohacker Collective at the forefront in developing groundbreaking formulas that deliver real results.
How Does Qualia Night Support Optimized Sleep?
✓It addresses causes of poor sleep including supporting natural melatonin production, circadian rhythms, and homeostatic sleep drive. When these are supported, we experience better quality sleep, getting to deep, restorative sleep more quickly.
✓Contains polyphenols and other compounds that feed healthy gut bacteria, supporting gut microbiota and the gut-brain axis, which is critical for healthy brain and immune function.
✓Supports brain-derived neurotrophic factor (BDNF), an important compound the brain and nervous system makes to protect existing neurons and encourage the growth of new neurons, doing both in support of learning, memory, and higher thinking.
✓Supports stem cell function, which plays an important functional role in repair and regeneration.
✓Supports brain and nervous system antioxidant defenses, combining cell membrane antioxidants like astaxanthin and lycopene, with superfood extracts, and herbal tonics.
We fully publish all the research behind every product. Read our booklet about the science and research behind Qualia Night.
KSM-66 Ashwagandha® (Withania somnifera) Root Extract
We included KSM-66 Ashwagandha® because it supports sleep quality, relaxation, muscle recovery, cognitive function, immunity and a healthier stress response: These are the areas at the core of what Qualia Night was designed to deliver.*
Gotu Kola (Centella asiatica) Whole Herb Extract
We included gotu kola because, unlike many other nootropics that are best taken only at the beginning of the day, gotu kola is a great fit at the end of a day of a busy day because it is calming and supports repair and rejuvenation processes.*
Holy Basil (Ocimum sanctum) Leaf Extract
We included holy basil because it’s an adaptogen and one of the leading causes of poor sleep is hyperarousal—an overactive stress response and over aroused nervous system. Holy basil also supports mood, cognition and immunity. This combination makes it a perfect fit for nighttime relaxation and restoration.*
Reishi Mushroom (Ganoderma lucidum) Fruiting Body Extract
Reishi was included in Qualia Night because it supports sleep (without causing sleepiness) and calms/centers the mind. In addition to these traditional uses, modern research on reishi mushrooms has focused on immune system support and rejuvenating processes, including stem cell function.
Schisandra chinensis Fruit Extract
S. chinensis fruits are often described as being an adaptogen, supporting broad resistance to stress, and enhancing mental and physical performance. Another reason it was included is that in preclinical research S. chinensis fruits enhance calmness and relaxation, and support readiness for sleep.
Ziziphus jujuba Seed Extract
Ziziphus jujuba seeds were believed to alleviate stress and calm the mind and spirit. They are one of the most commonly used herbs for supporting sleep and relaxation in China and other parts of Asia, and were included in Qualia Night because of these traditional uses.
Polygala tenuifolia Root Extract
In Traditional Chinese Medicine, Polygala tenuifolia root was often used to reduce forgetfulness. Preclinical research suggests it supports brain protection and repair processes and molecules (such as BDNF and NGF), counters stress, supports sleep, and influences both adenosine and GABA signaling.
White Peony (Paeonia lactiflora) Root Extract
White peony root contains a compound called paeoniflorin that influences adenosine signaling—a molecule involved in the sleep homeostatic drive. In preclinical research paeoniflorin supports brain protection and repair processes, counters stress, influences learning, and promotes a balanced mood.
Hawthorn Leaf and Flower Extract
The leaf and flowers of Hawthorn—Crataegus sp. such as C. monogyna and C. oxyacantha—was a heart tonic (i.e., something intended to make the heart function more efficiently) in European herbal traditions. It was included in Qualia Night because we wanted to include support for heart rejuvenation, and using an herb that has a reputation for calming and sleep supportive properties made it a perfect fit.*
Saffron Stigma Extract
Saffron is a spice derived from the flowers of Crocus sativus. Saffron is a source of crocin, picrocrocin, and safranal as well as the macular (eye) carotenoids zeaxanthin and lycopene. We felt saffron would be a fit in Qualia Night because of a combination of sleep support, mood enhancement, and relaxation.*
Vineatrol®20 Grapevine Extract
During our research on the homeostatic sleep drive, we discovered preclinical and animal studies indicating that resveratrol interacts with this system. We also found mentions of low doses of resveratrol benefiting sleep quality and next day feelings of being refreshed in news articles.
Olivex® Olive Fruit Extract
Olive polyphenols have been receiving attention for heart and brain health, as well as healthy aging and ATP production. Adenosine—the “A” in ATP—is believed to be the key molecule in the homeostatic sleep drive.
Wild Blueberry Fruit Extract
Blueberry polyphenols serve many roles in our formula. They support the gut-brain axis, support cognitive function and synergistically enhance the grape extracts we included in Qualia Night. Blueberries have also been found to support healthy stem cell activity in animal studies, supporting rejuvenation functions.
Sesame Seed Extract
Qualia Night included a sesame seed extract because the product’s goals included a focus on brain health, the gut-brain axis, and repair functions and molecules like BDNF. Sesame seeds contain a compound called sesamin that supports these areas, and is complementary with other ingredients.
γ-Oryzanol has interesting animal research that suggests its sleep supportive actions might be related to histamine signaling. Circadian changes on histamine neurotransmission play an important role in sleep-wake cycles and both daytime and night time performance.
AstaPure® Haematococcus pluvialis microalgae extract (3% astaxanthin)
We included astaxanthin in Qualia Night because of the growing body of research on cognitive function support, as well as protective, repair and regenerative processes in the brain. Also astaxanthin provides immune and gut-brain axis support.
Lycopene is one member in a class of natural pigments called carotenoids—carotenoids are fat-soluble yellow, orange, or red pigments. We included lycopene in Qualia Night because of a growing body of research, mostly in animals, suggesting support of protective, repair and regenerative processes in the brain.
L-tryptophan has been studied for and used to support healthier sleep. And, while high doses are often used, in a study that compared different dose amounts, a low dose performed the best.
L-theanine promotes alpha brain waves (α-waves), which are thought of as a marker of relaxation. L-theanine interacts with cells in innate and adaptive immunity, supporting general immune health.
Betaine has largely been used to support liver and heart health, with a prominent role in normalizing homocysteine metabolism. Newer research suggests betaine is an inhibitory neurotransmitter—neurons have betaine/GABA transporters. And there is increasing data to suggest that betaine may support cognition and neuroprotection.
Uridine (as Uridine-5'-monophosphoric acid disodium salt)
We included Uridine in Qualia Night for its central role in cellular metabolism, and because uridine is considered to be one of the natural sleep-promoting substances. We use a phosphorylated form of uridine because it is stable and this helps it get past the digestive system and liver intact.*
Grapefruit Whole Fruit Extract
We included a grapefruit extract standardized for naringin in this formula because of preclinical research suggesting that it may support enzymes in both adenosine—a key molecule in the sleep homeostatic drive—and GABA metabolic pathways. But we only included a very low amount of naringin—about what would be found in ⅓ of an ounce of grapefruit juice—because we did not want to substantially influence the activity of the cytochrome P450 enzymes that naringin may influence.
Quercetin (as Quercetin dihydrate)
Quercetin is a plant flavonol, which is one of the polyphenol categories. We included a small amount of quercetin for this formula because preclinical research suggests that it may support enzymes in both adenosine—a key molecule in the sleep homeostatic drive—and GABA pathways.*
Magnesium (as 400 mg magnesium glycinate)
Magnesium is used in more than 300 enzymes, including reactions in the GABA, an important relaxation neurotransmitter, and melatonin, the darkness hormone, signaling processes. Magnesium also plays a role in circadian rhythms, which are essential for healthy sleep-wake cycles. We choose to use a glycinate form of magnesium, because this form is often thought of as being the best choice for sleep support.
Vitamin B6 (as pyridoxal 5'-phosphate)
Pyridoxal 5'-phosphate (P5P) is the active form of vitamin B6. The P5P form is the bioactive form of vitamin B6: it requires less metabolic “work” to be used as coenzyme in vitamin B6-dependent enzyme reactions. P5P is included in this formula because it’s needed in the brain pathways that produce three important nighttime molecules—GABA, melatonin, and serotonin.*
Start getting the restorative sleep your body needs to regenerate and perform at its peak with Qualia Night. This unique patent-pending formula integrates clinically studied ingredients to give your body what it needs to have a relaxing evening and deep rejuvenating sleep.
When your body repairs fully at night you feel more energetic, focused, healthy, and resilient. Don’t just sleep better, optimize your body’s healing power at night.
What makes Qualia Night different is that it enhances sleep performance, empowering your body’s ability to heal, recover, and regenerate better night after night. Qualia Night is a whole-system solution to support deep sleep, cognition, immunity, and long-term sleep performance.
How does it do this? By enhancing BDNF, promoting GABA, balancing cortisol levels, and supporting gut microbiome health through a high purity blend of polyphenols, neuro-lipids, herbal adaptogens, therapeutic mushrooms, nootropics, Ayurvedic Rasayanas, superfoods, and cellular antioxidants. Wake up feeling recharged and refreshed with Qualia Night.
Amplifies Next Day
Energy & Performance
Clarity & Brain Health
Serving Size: 4
Servings Per Container: 20 (28 Day Supply)
Take up to 4 capsules at dinner or several hours before bedtime. This product is non-sedating and designed to be taken earlier in the evening (unlike before bedtime sleep aids). Night is designed to be taken 5 days on and 2 days off each week. It does not matter if the “off-cycle” days are consecutive or apart, so long as they happen each week.
|Amount per Serving||%DV|
|Vitamin B6 (as pyridoxal 5'-phosphate) 1.6 mg||94%|
|Magnesium (as magnesium glycinate) 50 mg||11%|
|Reishi Mushroom (Gonodermo lucidum) Fruiting Body Extract 500 mg||**|
|Holy Basil (Ocimum sanctum) Leaf Extract 250 mg||**|
|Hawthorn Leaf and Flower Extract 160 mg||**|
|Gotu Kola (Centella asiatica) Whole Herb Extract 150 mg||**|
|KSM-66 Ashwagandha® (Withania somnifera) Root Extract 150 mg||**|
|Schisandra chinensis Fruit Extract 130 mg||**|
|Wild Blueberry Fruit Extract 100 mg||**|
|Polygala tenuifolia Root Extract 100 mg||**|
|Ziziphus jujuba Seed Extract 100 mg||**|
|Betaine (trimethylglycine) 100 mg||**|
|L-Tryptophan 100 mg||**|
|Olivex® Olive Fruit Extract 80 mg||**|
|Sesame Seed Extract 50 mg||**|
|L-Theanine 50 mg||**|
|White Peony (Poeonio lactiflora) Root Extract 50 mg||**|
|AstaPure® Haematococcus pluvialis Microalgae Extract (3% astaxanthin) 33 mg||**|
|γ-Oryzanol 25 mg||**|
|Uridine (as Uridine-5'-monophosphoric acid disodium salt) 25 mg||**|
|Grapefruit Whole Fruit Extract 20 mg||**|
|Vineatrol®20 Grapevine Extract 20 mg||**|
|Saffron Stigma Extract 15 mg||**|
|Lycopene 4 mg||**|
|Quercetin (as Quercetin dihydrate) 2.5 mg||**|
|** Daily Value (DV) not established|
Other Ingredients: Hypromellose, Organic Rice Concentrate, Organic Rice Extract Blend
Olivex® is a registered trademark of Grap'Sud. AstaPure® is a registered trademark of Algatechnologies Ltd. KSM-66® is a registered trademark of Lxoreal Biomed Inc. VINEATROL is a registered trademark of ACTICHEM.
CAUTION: It should not be taken by pregnant or nursing mothers, or children under 18. If any undesired side effects are noticed, discontinue product immediately, and seek proper medical attention if needed.
"What makes Qualia Night innovative is how it delivers a holistic round-the-clock experience of evening relaxation, restorative sleep at night, and a productive next day."
"experienced a noticeable increase in energy, productivity, and endurance. I would like to start using it full time!"
"It promoted evening relaxation and sound sleep. But what I found most remarkable was the improved HRV."
"It relaxed me before bed, and increased my deep sleep score!"